Clinical Practice Guidelines

SIO is pleased to provide its updated clinical practice guidelines for breast cancer. In June 2018, ASCO announced endorsement of the guidelines. The guidelines were published in 2017. Researchers analyzed which integrative treatments are most effective and safe for patients with breast cancer. The guidelines are a resource for clinicians and patients to inform evidence-based decisions on the use of integrative therapies during breast cancer treatment. Researchers at US and Canadian institutions evaluated the efficacy and safety of more than 80 therapies.

The Journal of the National Cancer Institute Monograph has  published a special issue co-sponsored by SIO, "Advancing the Global Impact of Integrative Oncology"; including a comprehensive definition for integrative oncology. The articles in the special Monograph were all peer-reviewed.

JACM Special Issue on Integrative Palliative Care- Call for papers deadline has been extended. Read more here


Journal Cover
The Official Journal of:
Society for Acupuncture Research

Paradigm, Practice, and Policy Advancing Integrative Health
The Journal of Alternative and Complementary Medicine

Special Focus Issue on Integrative Palliative Care


 iocenters 2673328 1280 BoardRoomImage

SIO 2020 Call for Board Nominations is Open

The Society for Integrative Oncology (SIO) is accepting nominations from SIO members to fill anticipated vacancies on its Board of Trustees. SIO welcomes the nomination of individuals who are researchers, clinicians, clinical researchers, patients and patient advocates. The submission deadline is March 31, 2020.

Eligibility: To be eligible, candidates must meet the following criteria:
• Current SIO Member (or will join)
• Interested in and committed to advancing and maintaining the integrity of integrative oncology
• Willing to contribute at least 5-10 hours per month toward SIO activities
• Willing to participate in SIO advancement, including fund raising
• Willing to participate in the annual SIO conference (2020 conference will be held October 16-18 in Baltimore, MD)
• Willing to participate in teleconference call meetings every other month and attend and participate in one annual Board retreat and meeting at the SIO Conference. (The 2020 daylong retreat to be held October 15 from 8 a.m.-4 p.m. in Baltimore, MD.)
• Willing to co-chair an SIO Committee, Task Force and/or Special Interest Group

Read complete details here.

SIO2019 Conference Video Presentations Available on VuMedi

As a resource to SIO conference attendees, presentations from SIO's 16th International Conference in NYC are now accessible through, a video hosting platform that posts content from a broad range of healthcare organizations and medical professionals.

There are a total of 29 videos available, which were recorded in Gramercy East/West conference room over the course of the three-day conference. The conference program is also available and downloadable through is a complimentary service, but you do need to join the site before viewing presentations. Please follow the link provided here and scroll to the bottom of the page to create your account. It may take up to one hour for your account profile to be accepted, and you will receive a notification via email. You will not be able to view the presentations until you have received the acceptance notification.For those who are already VuMedi members, simply sign in and enter Society for Integrative Oncology in the search bar.Oral abstracts and presentations are also available to conference attendees through the Member portal of the SIO website. These presentations are restricted to conference attendees for three months. We will make them available to the general membership in February 2020. 

Complimentary Therapies for Cancer– Digest – February 2016

Our current literature update includes:



Strizich G; Gammon MD; Jacobson JS; Wall M; Abrahamson P; Bradshaw PT; Terry MB; Teitelbaum S; Neugut AI; Greenlee H.
Latent class analysis suggests four distinct classes of complementary medicine users among women with breast cancer.
BMC Complementary & Alternative Medicine. 15(1):411, 2015.
BACKGROUND: Breast cancer patients commonly report using >1 form of complementary and alternative medicine (CAM). However, few studies have
attempted to analyze predictors and outcomes of multiple CAM modalities. We sought to group breast cancer patients by clusters of type and intensity of complementary and alternative medicine (CAM) use following diagnosis.

METHODS: Detailed CAM use following breast cancer diagnosis was assessed in 2002-2003 among 764 female residents of Long Island, New York diagnosed with breast cancer in 1996-1997. Latent class analysis (LCA) was applied to CAM modalities while taking into account frequency and intensities.

RESULTS: Four distinct latent classes of CAM use emerged: 1) "Low-dose supplement users" (40 %), who used only common nutritional supplements; 2) "Vitamin/mineral supplement users" (39 %), using an abundance of supplements in addition to other practices; 3) "Mind-body medicine users" (12 %), with near-universal use of supplements, mind-body medicine techniques, and massage; and 4) "Multi-modality high-dose users" (9 %), who were highly likely to use nearly all types of CAM. Predictors of membership in classes with substantial CAM use included younger age, more education, higher income, Jewish religion, ideal body mass index, higher fruit and vegetable intake, higher levels of physical activity, receipt of adjuvant chemotherapy, and prior use of oral contraceptives.

CONCLUSIONS: LCA identified important subgroups of breast cancer patients characterized by varying degrees of complementary therapy use. Further research should explore the reproducibility of these classes and investigate the association between latent class membership and breast cancer outcomes.


Wu X; Chung VCh; Hui EP; Ziea ET; Ng BF; Ho RS; Tsoi KK; Wong SY;
Wu JC.
Effectiveness of acupuncture and related therapies for palliative care of cancer: overview of systematic reviews.
Scientific Reports. 5:16776, 2015.
Acupuncture and related therapies such as moxibustion and transcutaneous electrical nerve stimulation are often used to manage cancer-related symptoms, but their effectiveness and safety are controversial. We conducted this overview to summarise the evidence on acupuncture for palliative care of cancer. Our stematic review synthesised the results from clinical trials of patients with any type of cancer. The methodological quality of the 23 systematic reviews in this overview, assessed using the Methodological Quality of Systematic Reviews Instrument, was found to be satisfactory. There is evidence for the therapeutic effects of acupuncture for the management of cancer-related fatigue, chemotherapy-induced nausea and vomiting and leucopenia in patients with cancer. There is conflicting evidence regarding the treatment of cancer-related pain, hot flashes and hiccups, and improving patients' quality of life. The available evidence is currently insufficient to support or refute the potential of acupuncture and related therapies in the management of xerostomia, dyspnea and lymphedema and in the improvement of psychological well-being. No serious adverse effects were reported in any study. Because acupuncture appears to be relatively safe, it could be considered as a complementary form of palliative care for cancer, especially for clinical problems for which conventional care options are limited.


Tao W; Luo X; Cui B; Liang D; Wang C; Duan Y; Li X; Zhou S; Zhao M; Li Y; He Y; Wang S; Kelley KW; Jiang P; Liu Q.
Practice of traditional Chinese medicine for psycho-behavioral intervention improves quality of life in cancer patients: A systematic review and meta-analysis.
Oncotarget. 6(37):39725-39, 2015 Nov 24.
BACKGROUND: Cancer patients suffer from diverse symptoms, including depression, anxiety, pain, and fatigue and lower quality of life (QoL) during disease progression. This study aimed to evaluate the benefits of Traditional Chinese Medicine psycho-behavioral interventions (TCM PBIs) on improving QoL by meta-analysis.
RESULTS: The six TCM PBIs analyzed were acupuncture, Chinese massage, Traditional Chinese Medicine five elements musical intervention (TCM FEMI), Traditional Chinese Medicine dietary supplement (TCM DS), Qigong and Tai Chi. Although both TCM PBIs and non-TCM PBIs reduced functional impairments in cancer patients and led to pain relief, depression remission, reduced time to flatulence following surgery and sleep improvement, TCM PBIs showed more beneficial effects as assessed by reducing both fatigue and gastrointestinal distress. In particular, acupuncture relieved fatigue, reduced diarrhea and decreased time to flatulence after surgery in cancer patients, while therapeutic Chinese massage reduced time to flatulence and time to peristaltic sound.
METHODS: Electronic literature databases (PubMed, CNKI, VIP, and Wanfang) were searched for randomized, controlled trials conducted in China. The primary intervention was TCM PBIs. The main outcome was health-related QoL (HR QoL) post-treatment. We applied standard meta analytic techniques to analyze data from papers that reached acceptable criteria.
CONCLUSION: These findings demonstrate the efficacy of TCM PBIs in improving QoL in cancer patients and establish that TCM PBIs represent beneficial adjunctive therapies for cancer patients.

Hooke MC; Gilchrist L; Foster L; Langevin M; Lee J.
Yoga for Children and Adolescents After Completing Cancer Treatment.
Journal of Pediatric Oncology Nursing. 33(1):64-73, 2016 Jan.
Survivors of childhood cancer may experience persistent symptoms, including fatigue, sleep disturbance, and balance impairment. Yoga is a complementary therapy that improves fatigue, sleep, and quality of life in adult cancer survivors. Using a one group, repeated measures design, we evaluated the feasibility of a yoga program and assessed if cancer survivor participants ages 10 to 17 years (n = 13) had significantly less fatigue and anxiety, and better balance and sleep, after a 6-week yoga intervention compared with a 6-week pre-intervention wait period. Study recruitment was challenging with a 32% enrollment rate; yoga attendance was 90%. None of the scores for anxiety, fatigue, sleep, and balance had significant changes during the wait period. After the 6-week yoga program children (n = 7) had a significant decrease in anxiety score (P = .04) while adolescent scores (n = 7) showed a decreasing trend (P = .10). Scores for fatigue, sleep, and balance remained stable post-intervention. Fatigue and balance scores were below norms for health children/adolescents while sleep and anxiety scores were similar to healthy peers.


Tacani PM; Franceschini JP; Tacani RE; Machado AF; Montezello D; Goes
JC; Marx A.
Retrospective study of the physical therapy modalities applied in head and neck lymphedema treatment.
Head & Neck. 38(2):301-8, 2016 Feb.
BACKGROUND: Secondary lymphedema after head and neck cancer treatment is a serious complication and its management can be a challenge. The purpose of this study was to verify which physical therapy modalities were applied in the treatment of head and neck lymphedema through a retrospective analysis.
METHODS: A retrospective study was developed, based on the analysis of medical records of 32 patients treated in the physiotherapy outpatient department of the Brazilian Institute of Cancer Control (IBCC).
RESULTS: The physiotherapy included manual lymphatic drainage, massage, exercises, patient education, and compression therapy with an average of 23.9+/-14.8 sessions. Measurement results showed a significant reduction of face and neck lymphedema (p<.05) and pain (from 7.8+/-2.2 to 3.6+/-1.6; p<.001).
CONCLUSION: The physical therapy modalities based on strategic manual lymphatic drainage, shoulder girdle massage, facial, tongue and neck exercises, compressive therapy at home, and patient education showed reduction of the lymphedema and pain, both of them secondary to head and neck cancer treatment.


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